Phenotypes Associated with This Genotype

Genotype
MGI:2450607

• Allelic Composition: Hbb-b1^tm1Shs/Hbb-b1^tm1Shs
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:78271 )

• splenomegaly, 2.8 times heavier than wild-type controls; iron accumulation in spleen

enhanced bone marrow erythropoiesis ( J:78271 )

• seen in bone marrow, showing increased erythropoiesis with the appearance of megaloblastic cells

extramedullary hematopoiesis ( J:78271 )

• marked, in the red pulp of the spleen

hemolytic anemia ( J:78271 )

hypochromic anemia ( J:78271 )

• microspheric hypochromic anemia

increased erythroid progenitor cell number ( J:78271 )

decreased erythrocyte cell number ( J:78271 )

decreased hematocrit ( J:78271 )

decreased mean corpuscular hemoglobin ( J:78271 )

decreased mean corpuscular volume ( J:78271 )

anisopoikilocytosis ( J:78271 )

increased number of Heinz bodies ( J:78271 )

• 10 days after splenectomy, erythrocytes exhibit Heinz bodies which are rarely seen in wild-type mice

reticulocytosis ( J:78271 )

• with presence of nucleated RBC precursors

increased spleen iron level ( J:78271 )

abnormal erythrocyte physiology ( J:78271 )

• mutant erythrocytes show less of an affinity on oxygen saturation than wild-type erythrocytes

• erythrocytes have a shortened lifespan

immune system

enlarged spleen ( J:78271 )

• splenomegaly, 2.8 times heavier than wild-type controls; iron accumulation in spleen

increased spleen iron level ( J:78271 )

homeostasis/metabolism

increased spleen iron level ( J:78271 )

growth/size/body

enlarged spleen ( J:78271 )

• splenomegaly, 2.8 times heavier than wild-type controls; iron accumulation in spleen