Phenotypes Associated with This Genotype

Genotype
MGI:2450564

• Allelic Composition: Ace^tm1Unc/Ace⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:25284 )

• at weaning, the proportions of wild-type and heterozygous offspring differ significantly from the expected Mendelian ratios; the cause of this deviation has not been determined

cardiovascular system

hypotension ( J:25284 )

• blood pressure is reduced by 15-20 mm Hg in males; females display normal blood pressure

growth/size/body

increased body weight ( J:128859 )

• compared to in Ace^tm3Unc heterozygotes when fed a high fat diet

adipose tissue

abnormal epididymal fat pad morphology ( J:128859 )

• when fed a high fat diet, peri-epididymal adipose tissue is increased compared to in Ace^tm3Unc heterozygotes

reproductive system

reproductive system phenotype ( J:46177 )

N • males heterozygotes sire wild-type and heterozygous offspring at an indistinguishable frequency, indicating functionally intact sperm

endocrine/exocrine glands

increased insulin secretion ( J:128859 )

• compared to in Ace^tm3Unc heterozygotes when fed a high fat diet

homeostasis/metabolism

increased insulin secretion ( J:128859 )

• compared to in Ace^tm3Unc heterozygotes when fed a high fat diet