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Phenotypes Associated with This Genotype
Genotype
MGI:2450130
Allelic
Composition
Fancctm1Mab/Fancctm1Mab
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancctm1Mab mutation (0 available); any Fancc mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• deficient germinative stroma
• presence of spermatidic giant cells
• 73% of young (1.5-4 mo) and 83% of older (7-10 mo) female mice were sterile
• 40% of young (1.5-4 mo) and 67% of older (7-10 mo) male mice were sterile
• successful matings of homozygous mutant and wild-type mice yielded litters of reduced size

endocrine/exocrine glands
• deficient germinative stroma

hematopoietic system
N
• normal hematocrit, hemoglobin, erythrocyte, leukocyte, and platelet counts through 9 mo of age
• pre-B colony forming units are decreased compared to controls
• in 8 week old, but not older, mice
• following stimulation with TNF-alpha and CCL3/MIP1alpha, immature and differentiated myeloid hematopoietic cells exhibit increased apoptosis compared with controls
• hematopoietic progenitors exhibit increased sensitivity to methylmethanesulfonate and multiple inhibitory cytokines (IFN-gamma, TNF-alpha, and CCL3/MIP1alpha) compared with similarly treated control cells
• cultured hematopoietic progenitor cells exhibit increased suicide compared with control cells

cellular
• in hematopoietic progenitor cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Fanconi Anemia, Complementation Group C; FANCC 227645 J:32080


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory