Phenotypes Associated with This Genotype

Genotype
MGI:2450114

• Allelic Composition: Ntrk2^tm1Lfr/Ntrk2^tm1Lfr; Tg(Camk2a-cre)1Lfr/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal somatosensory cortex morphology ( J:77452 )

• compression occurs

abnormal visual cortex morphology ( J:77452 )

• severe compression of layers II/III and layer V of the visual cortex

abnormal neuron morphology ( J:77452 )

• mice exhibit a loss of Pou3f1-expressing neurons

• neuron cell bodies exhibit a 27% reduction in size with round morphology

abnormal dendrite morphology ( J:77452 )

• dendrites are thin and exhibit reduced complexity

• primary dendrites possess fewer and/or shorter branches

• the average apical diameter of a dendrite is reduced by 41% compared to in heterozygotes

decreased neuron number ( J:77452 )

• mice exhibit a loss of Pou3f1-expressing neurons