Phenotypes Associated with This Genotype

Genotype
MGI:2450105

• Allelic Composition: Apoe^{tm1(APOE_i4)Sfu}/Apoe^{tm1(APOE_i4)Sfu}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:60590 )

• serum total cholesterol level is 2.5-fold greater compared to wild-type

increased circulating LDL cholesterol level ( J:60590 )

• 60% of cholesterol is composed of LDL and VLDL

increased circulating VLDL cholesterol level ( J:60590 )

• 60% of cholesterol is composed of LDL and VLDL

decreased brain cholesterol level ( J:60590 )

• 30% reduction in total cholesterol in the brain

abnormal phospholipid level ( J:60590 )

• exhibit a reduction in phospholipid content in the brain

nervous system

abnormal brain morphology ( J:60590 )

• exhibit a reduction in phospholipid content and a 30% reduction in total cholesterol in the brain, although brain size is normal

decreased brain cholesterol level ( J:60590 )

• 30% reduction in total cholesterol in the brain