Phenotypes Associated with This Genotype

Genotype
MGI:2449988

• Allelic Composition: Snai1^tm1Grid/Snai1^tm1Grid
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:72861 )

• by E8.5, homozygous mutant embryos are in the process of resorption

embryo

abnormal gastrulation ( J:72861 )

• at E7.5, homozygous mutant embryos show defects in gastrulation and in the epithelial-mesenchymal transition required for normal formation of the mesoderm cell layer

abnormal mesoderm development ( J:72861 )

• at E7.5, most mutant embryos exhibit cavities or lacunae in the mesoderm layer, and the mesoderm cells lining these lacunae retain the morphology of an ordered columnar epithelium instead of having the typical mesenchymal morphology of wild-type mesoderm cells

• mutant mesoderm displays an apical-basal polarity that is characteristic of an epithelial cell layer

• mutant mesoderm cells contain microvilli at the apical surface facing into the lacunae and display numerous electron-dense adhesive junctions between cells

• at E7.5, E-cadherin expression is abnormally retained in the mesoderm of mutant embryos, although at lower levels than those observed in embryonic ectoderm

embryonic growth retardation ( J:72861 )

• by E8.5, homozygous mutant embryos appear severely retarded relative to wild-type embryos

decreased embryo size ( J:72861 )

• at E7.5, homozygous mutant embryos are smaller than wild-type embryos

absent amnion ( J:72861 )

• although a posterior amniotic fold forms, no amnion is observed at E7.5

absent chorion ( J:72861 )

• no chorion is observed at E7.5

growth/size/body

embryonic growth retardation ( J:72861 )

• by E8.5, homozygous mutant embryos appear severely retarded relative to wild-type embryos

decreased embryo size ( J:72861 )

• at E7.5, homozygous mutant embryos are smaller than wild-type embryos