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Phenotypes Associated with This Genotype
Genotype
MGI:2449985
Allelic
Composition
Faslpr-cg/Faslpr-cg
Genetic
Background
CBA/KlJms-Faslpr-cg/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr-cg mutation (3 available); any Fas mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• earliest deaths at 19 and 29 weeks of age (J:24805)
• survival rate at 1 year is 61.1% in males and 46.2% in females (J:24805)
• earliest deaths at 19 and 29 weeks of age (J:24805)
• survival rate at 1 year is 61.1% in males and 46.2% in females (J:24805)

immune system
• anomalous differentiation of T cells, with anomalous expression of surface antigens (J:24805)
• anomalous differentiation of T cells, with anomalous expression of surface antigens (J:24805)
• five times higher than in controls (J:81770)
• five times higher than in controls (J:81770)
• two times higher than in controls (J:81770)
• two times higher than in controls (J:81770)
• palpable by 3 months of age (J:24805)
• palpable by 3 months of age (J:24805)
• spleens larger in females than males (J:81770)
• spleen weights increase up to 6 months of age and remain at a plateau thereafter (J:81770)
• spleens larger in females than males (J:81770)
• spleen weights increase up to 6 months of age and remain at a plateau thereafter (J:81770)
• enlargement of the superficial lymph nodes starts at about 2.5 months of age, with cervical preceding inguinal lymph nodes (J:24805)
• superficial lymph nodes are more than 5 and 15 times heavier than controls at 3 and 5 months of age, respectively (J:24805)
• mesenteric lymph nodes are normal in size (J:24805)
• enlargement of the superficial lymph nodes starts at about 2.5 months of age, with cervical preceding inguinal lymph nodes (J:24805)
• superficial lymph nodes are more than 5 and 15 times heavier than controls at 3 and 5 months of age, respectively (J:24805)
• mesenteric lymph nodes are normal in size (J:24805)
• lymphocyte infiltration in liver, lungs, spleen, and kidneys (J:24805)
• lymphocyte infiltration in liver, lungs, spleen, and kidneys (J:24805)
• elevated levels of autoantibodies to nuclear antigens including anti-DNA (J:24805)
• elevated levels of autoantibodies to nuclear antigens including anti-DNA (J:24805)

hematopoietic system
• anomalous differentiation of T cells, with anomalous expression of surface antigens (J:24805)
• anomalous differentiation of T cells, with anomalous expression of surface antigens (J:24805)
• palpable by 3 months of age (J:24805)
• palpable by 3 months of age (J:24805)
• spleens larger in females than males (J:81770)
• spleen weights increase up to 6 months of age and remain at a plateau thereafter (J:81770)
• spleens larger in females than males (J:81770)
• spleen weights increase up to 6 months of age and remain at a plateau thereafter (J:81770)
• five times higher than in controls (J:81770)
• five times higher than in controls (J:81770)
• two times higher than in controls (J:81770)
• two times higher than in controls (J:81770)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autoimmune Lymphoproliferative Syndrome; ALPS 601859 J:24805 , J:81770


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory