Phenotypes Associated with This Genotype

Genotype
MGI:2449978

• Allelic Composition: Pik3cd^tm1.1Bvan/Pik3cd^tm1.1Bvan
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:78412 )

• mixed leukocyte infiltrates and regenerative changes in the glandular epithelium

abnormal intestinal mucosa morphology ( J:78412 )

• mucosal hyperplasia

crypts of Lieberkuhn abscesses ( J:78412 )

intestinal inflammation ( J:78412 )

• animals develop mild inflammatory bowel disease

endocrine/exocrine glands

crypts of Lieberkuhn abscesses ( J:78412 )

hematopoietic system

abnormal B cell differentiation ( J:78412 )

• CD23-CD21+IgM+ marginal zone B cells nearly undetectable

increased neutrophil cell number ( J:78412 )

• peripheral blood neutrophils increased two-fold

decreased B-1 B cell number ( J:78412 )

• CD5+IgM+ peritoneal B-1 cells nearly undetectable

spleen hypoplasia ( J:78412 )

• 50% reduction in spleen cell count compared to wild-type

absent spleen germinal center ( J:78412 )

decreased immunoglobulin level ( J:78412 )

• decreased serum level of immunoglobulin

decreased IgA level ( J:78412 )

• IgM and IgA most commonly reduced

decreased IgM level ( J:78412 )

• IgM and IgA most commonly reduced

immune system

intestinal inflammation ( J:78412 )

• animals develop mild inflammatory bowel disease

abnormal B cell differentiation ( J:78412 )

• CD23-CD21+IgM+ marginal zone B cells nearly undetectable

increased neutrophil cell number ( J:78412 )

• peripheral blood neutrophils increased two-fold

decreased B-1 B cell number ( J:78412 )

• CD5+IgM+ peritoneal B-1 cells nearly undetectable

spleen hypoplasia ( J:78412 )

• 50% reduction in spleen cell count compared to wild-type

absent spleen germinal center ( J:78412 )

decreased immunoglobulin level ( J:78412 )

• decreased serum level of immunoglobulin

decreased IgA level ( J:78412 )

• IgM and IgA most commonly reduced

decreased IgM level ( J:78412 )

• IgM and IgA most commonly reduced

abnormal Peyer's patch germinal center morphology ( J:78412 )

• absence of germinal centers