Mouse Genome Informatics
ot
    Cybbtm1Din/Y
involves: 129S/SvEv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• body weight is slightly but significantly reduced at 10-12 weeks of age (J:115614)

immune system
• neutrophils lacked respiratory burst activity (J:22868)
• macrophages lacked respiratory burst activity (J:22868)
• dysregulated inflammatory response; increased numbers of peritoneal exudate neutrophils in chemical peritonitis induced by thioglycollate (J:22868)
• increased frequency of spontaneously occurring infections (J:22868)
• increased susceptibility to S. aureus infection and A. fumigatus infection (J:22868)

cardiovascular system
• medial area of the aorta is unaffected by angiotensin II infusion whereas it increases in controls (J:115614)
• Angiotensin II infusion causes a 5% cardiac mass change as compared to a 20% change in controls (J:115652)
• baseline blood pressure is significantly reduced at 10-12 weeks of age (J:115614)
• lower baseline systolic pressure (J:115652)

hematopoietic system
• neutrophils lacked respiratory burst activity (J:22868)
• macrophages lacked respiratory burst activity (J:22868)

Mouse Models of Human Disease
OMIM IDRef(s)
Granulomatous Disease, Chronic, X-Linked; CGD 306400 J:22868