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Phenotypes Associated with This Genotype
Genotype
MGI:2449556
Allelic
Composition
Cybbtm1Din/Y
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cybbtm1Din mutation (1 available); any Cybb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• body weight is slightly but significantly reduced at 10-12 weeks of age (J:115614)
• body weight is slightly but significantly reduced at 10-12 weeks of age (J:115614)

immune system
• neutrophils lacked respiratory burst activity (J:22868)
• neutrophils lacked respiratory burst activity (J:22868)
• macrophages lacked respiratory burst activity (J:22868)
• macrophages lacked respiratory burst activity (J:22868)
• dysregulated inflammatory response; increased numbers of peritoneal exudate neutrophils in chemical peritonitis induced by thioglycollate (J:22868)
• dysregulated inflammatory response; increased numbers of peritoneal exudate neutrophils in chemical peritonitis induced by thioglycollate (J:22868)
• increased frequency of spontaneously occurring infections (J:22868)
• increased frequency of spontaneously occurring infections (J:22868)
• increased susceptibility to S. aureus infection and A. fumigatus infection (J:22868)
• increased susceptibility to S. aureus infection and A. fumigatus infection (J:22868)

cardiovascular system
• medial area of the aorta is unaffected by angiotensin II infusion whereas it increases in controls (J:115614)
• medial area of the aorta is unaffected by angiotensin II infusion whereas it increases in controls (J:115614)
• Angiotensin II infusion causes a 5% cardiac mass change as compared to a 20% change in controls (J:115652)
• Angiotensin II infusion causes a 5% cardiac mass change as compared to a 20% change in controls (J:115652)
• baseline blood pressure is significantly reduced at 10-12 weeks of age (J:115614)
• baseline blood pressure is significantly reduced at 10-12 weeks of age (J:115614)
• lower baseline systolic pressure (J:115652)
• lower baseline systolic pressure (J:115652)

hematopoietic system
• neutrophils lacked respiratory burst activity (J:22868)
• neutrophils lacked respiratory burst activity (J:22868)
• macrophages lacked respiratory burst activity (J:22868)
• macrophages lacked respiratory burst activity (J:22868)

Mouse Models of Human Disease
OMIM ID Ref(s)
Granulomatous Disease, Chronic, X-Linked; CGD 306400 J:22868


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory