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Phenotypes Associated with This Genotype
Genotype
MGI:2449544
Allelic
Composition
F8tm1Kaz/Y
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F8tm1Kaz mutation (2 available); any F8 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit a reduced ability to clot blood upon tail cutting, with most animals dying within 2 hours of tail snipping unless cauterized (J:24941)
• 2/3 males die within 2 hours of tail snipping from excessive bleeding (J:36698)

homeostasis/metabolism
• male hemizygous mice exhibit hemophilia (J:24941)
• mice exhibit a reduced ability to clot blood upon tail cutting, with most animals dying within 2 hours of tail snipping unless cauterized (J:24941)
• plasma from mutant mice exhibits a prolonged clotting time compared to controls (J:24941)
• 2/3 males die within 2 hours of tail snipping from excessive bleeding (J:36698)

hematopoietic system
N
• no spontaneous bleeding is observed into joints or soft tissues up to 12 weeks of age (J:24941)
• males exhibit no spontaneous bleeding, illness or reduction in activity up to 1 year of age (J:36698)

immune system
• mutants develop anti-factor VIII antibodies following administration of factor VIII

Mouse Models of Human Disease
OMIM ID Ref(s)
Hemophilia A; HEMA 306700 J:24941 , J:178969


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory