Mouse Genome Informatics
ot
    F8tm1Kaz/Y
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mice exhibit a reduced ability to clot blood upon tail cutting, with most animals dying within 2 hours of tail snipping unless cauterized (J:24941)
• 2/3 males die within 2 hours of tail snipping from excessive bleeding (J:36698)

homeostasis/metabolism
• male hemizygous mice exhibit hemophilia (J:24941)
• mice exhibit a reduced ability to clot blood upon tail cutting, with most animals dying within 2 hours of tail snipping unless cauterized (J:24941)
• plasma from mutant mice exhibits a prolonged clotting time compared to controls (J:24941)
• 2/3 males die within 2 hours of tail snipping from excessive bleeding (J:36698)

hematopoietic system
N
• no spontaneous bleeding is observed into joints or soft tissues up to 12 weeks of age (J:24941)
• males exhibit no spontaneous bleeding, illness or reduction in activity up to 1 year of age (J:36698)

immune system
• mutants develop anti-factor VIII antibodies following administration of factor VIII (J:178969)

Mouse Models of Human Disease
OMIM IDRef(s)
Hemophilia A; HEMA 306700 J:24941 , J:178969