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Phenotypes Associated with This Genotype
Genotype
MGI:2449063
Allelic
Composition
C3tm1Hrc/C3tm1Hrc
Genetic
Background
either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Hrc mutation (2 available); any C3 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• a 2000-fold increase in pneumococci is seen compared to wild-type littermates following infection with S. pneumoniae

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
complement component 3 deficiency DOID:8354 OMIM:613779
J:56193


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory