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Phenotypes Associated with This Genotype
Genotype
MGI:2448997
Allelic
Composition
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Genetic
Background
C.129S4-Fcgr2btm1Ttk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice have life spans comparable to wild-type littermates

immune system
• mice infected with Plasmodium chabaudi chabaudi exhibit lower peak levels of parasitemia and quicker resolution, less severe anemia, less severe hypothermia, increased phagocytosis of malarial parasites by macrophages, increased TNF-alpha production from macrophages ingesting malaria parasite and increased anti-malarial antibody titers compared with wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Malaria, Susceptibility to 611162 J:120905


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory