Mouse Genome Informatics
hm
    Rs1tmgc1/Rs1tmgc1
involves: C3H/Rl * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• microflecks and streaks seen in all males and about 61% of females
• possibly due to the undulating pattern of the outer nuclear layer and the presence of rosettes
• small patchy areas of RPE depigmentation and clumping
• layer split in some regions
• clusters of photoreceptor nuclei migrate into inner and sometimes outer segments of the photoreceptor by 10 weeks of age
• more prevalent at 18 months
• sometimes disrupted by cell bodies of inner and outer nuclear layers
• expanded into inner nuclear layer by 18 months of age
• considerably shortened by 18 months of age
• sometimes disrupted by presence of photoreceptor nuclei
• occasionally also affected by presence of photoreceptor nuclei
• disrupted lamination of the retina
(J:81149)
• reduced amplitude of a and b waves on electroretinograms, particularly at higher flash intensities (J:99982)

nervous system
• sometimes disrupted by presence of photoreceptor nuclei
• occasionally also affected by presence of photoreceptor nuclei

pigmentation
• small patchy areas of RPE depigmentation and clumping

Mouse Models of Human Disease
OMIM IDRef(s)
Retinoschisis 1, X-Linked, Juvenile; RS1 312700 J:99982