Phenotypes Associated with This Genotype

Genotype
MGI:2448649

• Allelic Composition: Cd247^tm1Lov/Cd247^tm1Lov
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte number ( J:14170 )

• average number of thymocytes about 14% of control numbers

decreased double-positive T cell number ( J:14170 )

• decreased number of double positive thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:14170 )

• about 1% normal levels in thymus

absent gamma-delta intraepithelial T cell ( J:46914 )

• TCR gamma-delta T cells are virtually absent while alpha-beta lineages are readily detectable among intestinal epithelial lymphocytes

abnormal T-helper 1 cell morphology ( J:14170 )

• Th1 memory cell phenotype

abnormal single-positive T cell number ( J:14170 )

• reduced in number but significant numbers of single positive T-cells expressing low levels of CD5 and barely detectable levels of CD3 epsilon and TCR beta are found in lymph nodes present never the less

• deficient in both single positive thymocyte types

abnormal T-helper 1 physiology ( J:46914 )

• can be stimulated to produce large quantities of interferon gamma

• can be induced to produce Il2

nervous system

abnormal brain morphology ( J:66246 )

abnormal superior colliculus morphology ( J:66246 )

• retinal projections to the ipsilateral superior colliculus occasionally found

abnormal lateral geniculate nucleus morphology ( J:66246 )

• the area of ipsilateral projections to the dorsal lateral geniculate nucleus is enlarged

• ectopic projections are sometimes also found in mediodorsal areas

abnormal CNS synaptic transmission ( J:66246 )

abnormal excitatory postsynaptic potential ( J:66246 )

• increased slope of the field excitatory post synaptic potential

enhanced long-term potentiation ( J:66246 )

• in CA1 of the hippocampus after titanic stimulation

absent long-term depression ( J:66246 )

• not detectable

hematopoietic system

decreased thymocyte number ( J:14170 )

• average number of thymocytes about 14% of control numbers

decreased double-positive T cell number ( J:14170 )

• decreased number of double positive thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:14170 )

• about 1% normal levels in thymus

absent gamma-delta intraepithelial T cell ( J:46914 )

• TCR gamma-delta T cells are virtually absent while alpha-beta lineages are readily detectable among intestinal epithelial lymphocytes

abnormal T-helper 1 cell morphology ( J:14170 )

• Th1 memory cell phenotype

abnormal single-positive T cell number ( J:14170 )

• reduced in number but significant numbers of single positive T-cells expressing low levels of CD5 and barely detectable levels of CD3 epsilon and TCR beta are found in lymph nodes present never the less

• deficient in both single positive thymocyte types

abnormal T-helper 1 physiology ( J:46914 )

• can be stimulated to produce large quantities of interferon gamma

• can be induced to produce Il2

endocrine/exocrine glands

decreased thymocyte number ( J:14170 )

• average number of thymocytes about 14% of control numbers