Phenotypes Associated with This Genotype

Genotype
MGI:2448059

• Allelic Composition: Disp1^icb/Disp1^icb
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:79027 , J:98216 )

• embryos arrested at E9.0-E9.5 (J:79027)

• die at E9.0 (J:98216)

cardiovascular system

failure of heart looping ( J:79027 )

• embryos lacked asymmetrical heart looping

pericardial edema ( J:79027 )

craniofacial

abnormal head shape ( J:79027 )

• embryos possessed abnormally shaped heads

embryo

abnormal direction of embryo turning ( J:79027 )

• embryonic turning occurred in a randomized direction

abnormal left-right axis patterning ( J:98216 )

• left-right randomization

abnormal neural tube morphology ( J:79027 )

• neural tube was dorsalized

homeostasis/metabolism

pericardial edema ( J:79027 )

limbs/digits/tail

abnormal forelimb morphology ( J:79027 )

• embryos possessed relatively large forelimbs

nervous system

nervous system phenotype ( J:79027 )

N • intact notochord

abnormal neural tube morphology ( J:79027 )

• neural tube was dorsalized

abnormal spinal cord morphology ( J:98216 )

• dorsalized spinal cord

growth/size/body

abnormal head shape ( J:79027 )

• embryos possessed abnormally shaped heads