Phenotypes Associated with This Genotype

Genotype
MGI:2447868

• Allelic Composition: Adh7^tm1Gdu/Adh7^tm1Gdu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:76055 )

• retinol toxicity is increased in these mice with a LD50 that is 1.6-fold less than controls

homeostasis/metabolism

abnormal vitamin A level ( J:55555 )

• retinol-treated mutants have significantly lower levels of kidney retinoic acid than wild-type

abnormal ethanol metabolism ( J:56168 , J:55555 )

• defective ethanol clearance (J:56168)

• increase in ethanol-induced embryo resorption during pregnancy compared to controls (J:55555)

abnormal retinol metabolism ( J:56168 , J:76055 )

• reduced metabolism of retinal to retinoic acid (J:56168)

• retinol toxicity is increased in these mice with a LD50 that is 1.6-fold less than controls (J:76055)