Phenotypes Associated with This Genotype

Genotype
MGI:2447608

• Allelic Composition: Adcyap1^tm1Aba/Adcyap1^tm1Aba
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * ICR)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:72576 )

• incomplete penetrance

behavior/neurological

increased exploration in new environment ( J:72576 )

• increased activity in open field

decreased anxiety-related response ( J:72576 )

• reduced anxiety in open field emergence, elevated plus maze, and novel-object tests

decreased grooming behavior ( J:72576 )

hyperactivity ( J:72576 )

increased vertical activity ( J:72576 )

• rearing and jumping

reproductive system

reduced fertility ( J:72576 )

• homozygous matings resulted in fewer successful pregnanacies than littermate controls

reduced female fertility ( J:102717 )

♀ • Background Sensitivity: female fertility is more severely reduced on a mixed 129P2/OlaHsd x C57BL/6 genetic background (only 33% vs 85% in wild-type females) than on an outbred genetic background following 4-6 backcrosses onto the ICR strain (50% vs 87% in wild-type females)