Phenotypes Associated with This Genotype

Genotype
MGI:2446653

• Allelic Composition: Dcc^tm1Wbg/Dcc^tm1Wbg
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:39765 )

• mice died within 24 hours of birth

behavior/neurological

abnormal suckling behavior ( J:39765 )

• mice appeared unable to suckle

respiratory system

respiratory distress ( J:39765 )

• mice exhibited labored respirations

nervous system

abnormal commissural neuron axon guidance ( J:39765 )

• some misrouting of commissural axons that projected into the ventral spinal cord

absent corpus callosum ( J:39765 )

absent hippocampal commissure ( J:39765 )

• absent hippocampal commissure

abnormal pontine nuclei morphology ( J:39765 )

• absence of pontine nuclei from the hindbrain

abnormal spinal cord dorsal column morphology ( J:39765 )

• reduction in the number of commissural axons with the dorsal spinal cord of mice examined at E9.5-E11.5

cellular

abnormal commissural neuron axon guidance ( J:39765 )

• some misrouting of commissural axons that projected into the ventral spinal cord