mortality/aging
• mice died within 24 hours of birth
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behavior/neurological
• mice appeared unable to suckle
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respiratory system
• mice exhibited labored respirations
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nervous system
• some misrouting of commissural axons that projected into the ventral spinal cord
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• absent hippocampal commissure
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• absence of pontine nuclei from the hindbrain
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• reduction in the number of commissural axons with the dorsal spinal cord of mice examined at E9.5-E11.5
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cellular
• some misrouting of commissural axons that projected into the ventral spinal cord
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