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Phenotypes Associated with This Genotype
Genotype
MGI:2446598
Allelic
Composition
Acadvltm1Uab/Acadvltm1Uab
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acadvltm1Uab mutation (1 available); any Acadvl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• C16 and C18 acylcarnitines are elevated in bile, blood, and serum of fasted mutants (J:72193)
• C16 and C18 acylcarnitines are elevated in bile, blood, and serum of fasted mutants (J:72193)
• mild lipid accumulation in the heart is seen in fasted mutants (J:72193)
• mild lipid accumulation in the heart is seen in fasted mutants (J:72193)
• mild reduction in mitochondrial acyl-CoA dehydrogenase activity toward palmitoyl-CoA and oleoyl-CA in the liver (J:72193)
• mild reduction in mitochondrial acyl-CoA dehydrogenase activity toward palmitoyl-CoA and oleoyl-CA in the liver (J:72193)

liver/biliary system
• fasted mice display mild steatosis, with droplets of varying sizes in many hepatocytes (J:72193)
• fasted mice display mild steatosis, with droplets of varying sizes in many hepatocytes (J:72193)

cardiovascular system
• fasted mice display a mild, diffuse fatty change in hearts (J:72193)
• fasted mice display a mild, diffuse fatty change in hearts (J:72193)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory