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Phenotypes Associated with This Genotype
Genotype
MGI:2446598
Allelic
Composition
Acadvltm1Uab/Acadvltm1Uab
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acadvltm1Uab mutation (1 available); any Acadvl mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• C16 and C18 acylcarnitines are elevated in bile, blood, and serum of fasted mutants
• mild lipid accumulation in the heart is seen in fasted mutants
• mild reduction in mitochondrial acyl-CoA dehydrogenase activity toward palmitoyl-CoA and oleoyl-CA in the liver

liver/biliary system
• fasted mice display mild steatosis, with droplets of varying sizes in many hepatocytes

cardiovascular system
• fasted mice display a mild, diffuse fatty change in hearts

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
very long chain acyl-CoA dehydrogenase deficiency DOID:0080155 OMIM:201475
J:72193


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory