Phenotypes Associated with This Genotype

Genotype
MGI:2445833

• Allelic Composition: Atrn^mg/Atrn^mg
• Genetic Background: C3H/HeJ.Cg-Atrn^mg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:71075 )

• dark backs

• some yellow pigment in flank and ventral hairs

• reduced levels of pheomelanin and modest reductions in eumelanin

nervous system

brain vacuoles ( J:71075 )

• brain vacuoles appear between 2 and 4 months

growth/size/body

postnatal growth retardation ( J:71075 )

• both males and females weigh 10-15% less than controls by 3 months of age

adipose tissue

decreased total body fat amount ( J:71075 )

• 20-40% reduction in body fat

behavior/neurological

increased locomotor activity ( J:71075 )

• nocturnal locomotor activity is elevated 55-70%

integument

abnormal coat/hair pigmentation ( J:71075 )

• dark backs

• some yellow pigment in flank and ventral hairs

• reduced levels of pheomelanin and modest reductions in eumelanin