Phenotypes Associated with This Genotype

Genotype
MGI:2429492

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom
• Genetic Background: involves: 129S7/SvEvBrd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:1934 )

• thymus contains 15 to 300 times fewer cells than wild-type or heterozygous controls

abnormal B cell differentiation ( J:1934 )

• spleen and bone marrow lack mature B cells; B cells are IgM and IgD negative, and only 1/4 to 1/3 are B220-positive

abnormal immunoglobulin V(D)J recombination ( J:1934 )

• absence of V(D)J recombination

absent mature B cells ( J:1934 )

• no mature B lymphocytes are observed in lymphoid organs

abnormal T cell morphology ( J:1934 )

• thymocytes are larger in 4-, 5-, and 7-week old mutants than in controls

• no mature T lymphocytes are seen in lymphoid organs

abnormal T cell differentiation ( J:1934 )

• thymocyte development is arrested at an early stage; cells are larger than normal, and are CD3^-, TCR alphabeta-negative, CD8^- CD4^-

abnormal T cell receptor V(D)J recombination ( J:1934 )

• absence of V(D)J recombination

spleen hypoplasia ( J:1934 )

• spleen contains 5 to 9 times fewer nonerythroid cells than wild-type or heterozygous controls

decreased IgM level ( J:1934 )

• no detectable IgM found in serum

abnormal inguinal lymph node morphology ( J:1934 )

• stroma-like structure found in inguinal lymph nodes location, with few, if any, nonerythroid cells recoverable from this structure

hematopoietic system

thymus hypoplasia ( J:1934 )

• thymus contains 15 to 300 times fewer cells than wild-type or heterozygous controls

abnormal B cell differentiation ( J:1934 )

• spleen and bone marrow lack mature B cells; B cells are IgM and IgD negative, and only 1/4 to 1/3 are B220-positive

abnormal immunoglobulin V(D)J recombination ( J:1934 )

• absence of V(D)J recombination

absent mature B cells ( J:1934 )

• no mature B lymphocytes are observed in lymphoid organs

abnormal T cell morphology ( J:1934 )

• thymocytes are larger in 4-, 5-, and 7-week old mutants than in controls

• no mature T lymphocytes are seen in lymphoid organs

abnormal T cell differentiation ( J:1934 )

• thymocyte development is arrested at an early stage; cells are larger than normal, and are CD3^-, TCR alphabeta-negative, CD8^- CD4^-

abnormal T cell receptor V(D)J recombination ( J:1934 )

• absence of V(D)J recombination

spleen hypoplasia ( J:1934 )

• spleen contains 5 to 9 times fewer nonerythroid cells than wild-type or heterozygous controls

decreased IgM level ( J:1934 )

• no detectable IgM found in serum

nervous system

nervous system phenotype ( J:1934 )

N • brain is normal in structure and size

behavior/neurological

behavior/neurological phenotype ( J:1934 )

N • normal activity, coordination and strength; normal nociception

endocrine/exocrine glands

thymus hypoplasia ( J:1934 )

• thymus contains 15 to 300 times fewer cells than wild-type or heterozygous controls