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Phenotypes Associated with This Genotype
Genotype
MGI:2429456
Allelic
Composition		 Alox15tm1Fun/Alox15tm1Fun
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alox15tm1Fun mutation (3 available); any Alox15 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:44778 )
N
• no defect detected in pituitary gland, adrenals, and pancreas

hematopoietic system
hematopoietic system phenotype ( J:44778 )
N
• mutants had normal total blood cell counts, normal leukocyte differentials, normal reticulocyte numbers, normal hemoglobin values, and normal hematocrit values

immune system
abnormal immune system physiology ( J:44778 )
• altered arachadonic acid metabolism in peritoneal macrophages upon calcium ionophore stimulation: undetectable 12-hydroxyeicosatetraenoic acid (12-HETE), trace amounts of 15-hydroxyeicosatetraenoic acid (15-HETE), increased concentrations of 5-hydroxyeicosatetraenoic acid (5-HETE), however no defect detected in the spleen

reproductive system
reproductive system phenotype ( J:44778 )
N
• mutants were fertile

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory