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Phenotypes Associated with This Genotype
Genotype
MGI:2389022
Allelic
Composition
\Tg(Lck-Map3k8)3456Ngc/?
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice developed metastatic lymphoblastic lymphomas with an 88% incidence by 3 months of age
• tumors were shown to be of T-cell origin derived from cells at different stages of T-cell development

endocrine/exocrine glands
• mice developed metastatic lymphoblastic lymphomas with an 88% incidence by 3 months of age
• tumors were shown to be of T-cell origin derived from cells at different stages of T-cell development

hematopoietic system
• mice developed metastatic lymphoblastic lymphomas with an 88% incidence by 3 months of age
• tumors were shown to be of T-cell origin derived from cells at different stages of T-cell development

immune system
• mice developed metastatic lymphoblastic lymphomas with an 88% incidence by 3 months of age
• tumors were shown to be of T-cell origin derived from cells at different stages of T-cell development


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory