Analysis Tools
mortality/aging
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• approximately 50% of mice die around 2 weeks of age of undetermined cause
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pigmentation
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• on back and/or abdomen
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• on back and/or abdomen
• visible 3-5 days after birth
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endocrine/exocrine glands
cryptorchism
(
J:69948
)
 |
• small bilateral undescended testis located in the high intraabdominal position
• testes are located beneath the peritoneum near the kidney
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growth/size/body
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• transient; 15 to 25% decreased body weight during the first three months of life; however, by four months of age, mutants show no significant difference in body weight compared to wild-type
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reproductive system
azoospermia
(
J:69948
)
|
|
• in adults, only a few spermatogonial cells are present
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cryptorchism
(
J:69948
)
|
|
• small bilateral undescended testis located in the high intraabdominal position
• testes are located beneath the peritoneum near the kidney
|
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• extended gubernaculum
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• inguinal canal fails to form
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|
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• scrotal sac is not fully formed
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|
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• testes are histologically normal until day 15
• sterility of the males is due to location of the testis as spermatogenesis was restored in 4 week old mutant males when the testis was removed from the abdominal area and placed under the skin in the scrotal area
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integument
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• on back and/or abdomen
|
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• on back and/or abdomen
• visible 3-5 days after birth
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skeleton
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• extended gubernaculum
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cellular
azoospermia
(
J:69948
)
|
|
• in adults, only a few spermatogonial cells are present
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