Phenotypes Associated with This Genotype

Genotype
MGI:2388045

• Allelic Composition: Tg(Plp)66Kan/Tg(Plp)66Kan
• Genetic Background: involves: C57BL * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:17373 )

• die at approximately 2 months of age

behavior/neurological

tremors ( J:17373 )

• apparent by 2 weeks of age and progressive severity with age

ataxia ( J:17373 )

• apparent by 2 weeks of age and progressive severity with age

seizures ( J:17373 )

• apparent by 2 weeks of age and progressive severity with age

nervous system

seizures ( J:17373 )

• apparent by 2 weeks of age and progressive severity with age

astrocytosis ( J:17373 )

• widespresd astrocytosis in white matter areas of hypomylelinated structures

• increased number of processes

demyelination ( J:17373 )

• progressive with age

• more pronounced in forebrain and optic nerves

• less severe in the brainstem and spinal cord

• within the spinal cord, hypomyelination was more severe in the dorsal columns than in the ventral columns