Phenotypes Associated with This Genotype

Genotype
MGI:2386971

• Allelic Composition: Cdk4^tm1.1Bbd/Cdk4^tm1.1Bbd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:54534 )

• weigh 5 - 10% more than wild-type or heterozygous littermates

endocrine/exocrine glands

increased pancreatic beta cell number ( J:54534 )

• the pancreatic islet area is increased 7-10 fold, primarily die to increased beta-cell number, and resemble insulinomas

increased Leydig cell number ( J:54534 )

♂ • increased population of testicular Leydig cells

♂ • normal architecture of seminiferous tubules

♂ • normal germ- and Sertoli-cell development in the testes

♂ • males and females were fertile

♂ • normal female reproductive organs

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:54534 )

N • normal glucose levels

reproductive system

increased Leydig cell number ( J:54534 )

♂ • increased population of testicular Leydig cells

♂ • normal architecture of seminiferous tubules

♂ • normal germ- and Sertoli-cell development in the testes

♂ • males and females were fertile

♂ • normal female reproductive organs