Mouse Genome Informatics
hm
    Cdk4tm1Bbd/Cdk4tm1Bbd
involves: 129S1/Sv * 129X1/SvJ * ICR
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• slightly lower ratio of homozygotes produced from heterozygote matings (19.6%)

growth/size/body
• smaller size noticeable at birth and progressively more noticeable with age
• overall reduction in size of all major organs
• adults were 50% the weight of wild-type and heterozygous controls

cellular
• serum-starved fibroblasts derived from mutant mice exhibited a delay in reaching S phase when placed in a rich environment

homeostasis/metabolism
• in adult mice
• females had low circulating levels of follicle-stimulating hormone
• adult mice showed hypoinsulinemia
• females had low circulating levels of progesterone
• high glucose concentrations in urine
• ketone bodies in urine

reproductive system
• defect in corpus luteum formation
• severe reduction in spermatozoa in older males
• in males with limited fertility, reduced numbers of spermatids and mature sperm cells were evident
• degeneration of primary spermatocytes
• reduced numbers of Leydig cells with numerous apoptotic bodies
• vacuolized Sertoli-cell cytoplasm
• 75% reduction in size and weight of testes compared to controls
• moderately delayed estrous cycles
• infertile, failed to reproduce with wild-type males
• most sterile, 80% failed to induce pregnancy
• males that did produce offspring had small litters (3 - 6 pups) and reproduced only for a short period (2 - 3 months of age)

behavior/neurological
• impaired locomotion

renal/urinary system
• high glucose concentrations in urine
• ketone bodies in urine

endocrine/exocrine glands
• mice 2 months of age or older showed severe deformity and reduction in the size of the islets of the pancreas
• defect in corpus luteum formation
• degeneration of primary spermatocytes
• reduced numbers of Leydig cells with numerous apoptotic bodies
• vacuolized Sertoli-cell cytoplasm
• 75% reduction in size and weight of testes compared to controls

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:54534