Phenotypes for Abcb1a Abcb1b MGI:2386646 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Abcb1a^tm1Bor/Abcb1a^tm1Bor Abcb1b^tm1Bor/Abcb1b^tm1Bor
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1a^tm1Bor mutation (3 available); any Abcb1a mutation (93 available)
Abcb1b^tm1Bor mutation (2 available); any Abcb1b mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:39804 )

• altered pharmacokinetics of digoxin, with reduced elimination (and thus accumulation) of digoxin in the brain, adrenal glands, ovaries, and testis

• intestinal, but not biliary or urinary, excretion of digoxin is reduced in mice with a cannulated gallbladder

• intestinal, but not biliary or urinary, excretion of the anticancer drug paclitaxel is decreased compared to wild-type

• decreased rate of rhodamine efflux from hematopoietic progenitor cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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