Phenotypes Associated with This Genotype

Genotype
MGI:2386628

• Allelic Composition: Pax6^tm1Pgr/Pax6^tm1Pgr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal ventral interneuron morphology ( J:106437 )

abnormal ventral interneuron 0 morphology ( J:106437 )

• increase in the number of commissural V0 neurons in the spinal cord

abnormal ventral interneuron 1 morphology ( J:106437 )

• decrease in the number of V1 neurons

abnormal ventral interneuron 3 morphology ( J:106437 )

• increase in the number of commissural V3 neurons in the spinal cord

abnormal neuron physiology ( J:106437 )

• motor neurons show prolonged periods of membrane depolarization and continue to fire action potentials throughout the depolarized phase

abnormal CNS synaptic transmission ( J:106437 )

• significant increase in the length of both step cycle period and motor neuron burst duration during fictive locomotion

• decrease in sensitivity to NMDA and 5-hydroxytryptamine induced locomotor like activity in the spinal cord