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Phenotypes Associated with This Genotype
Genotype
MGI:2386166
Allelic
Composition
Cd74tm1Doi/Cd74tm1Doi
H2-DMatm1Doi/H2-DMatm1Doi
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Doi mutation (1 available); any Cd74 mutation (38 available)
H2-DMatm1Doi mutation (1 available); any H2-DMa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• significant mortality after a few weeks of age

growth/size/body
• showed runting

hematopoietic system
• reduction in the CD4+CD8- cell population and a compensatory increase in CD4-CD8+ cell population
• compensatory increase in CD4-CD8+ cell population due to reduction in the CD4+CD8- cell population

immune system
• reduction in the CD4+CD8- cell population and a compensatory increase in CD4-CD8+ cell population
• compensatory increase in CD4-CD8+ cell population due to reduction in the CD4+CD8- cell population
• antigen presenting cells (APCs) had defective protein and peptide presentation


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory