mortality/aging
• significant mortality after a few weeks of age
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growth/size/body
• showed runting
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hematopoietic system
• reduction in the CD4+CD8- cell population and a compensatory increase in CD4-CD8+ cell population
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• compensatory increase in CD4-CD8+ cell population due to reduction in the CD4+CD8- cell population
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immune system
• reduction in the CD4+CD8- cell population and a compensatory increase in CD4-CD8+ cell population
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• compensatory increase in CD4-CD8+ cell population due to reduction in the CD4+CD8- cell population
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• antigen presenting cells (APCs) had defective protein and peptide presentation
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