Phenotypes Associated with This Genotype

Genotype
MGI:2386165

• Allelic Composition: Cd74^tm1Doi/Cd74^tm1Doi
• Genetic Background: either: (involves: 129/Sv * B10.BR) or (involves: 129/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:45185 , J:4119 )

• reduced number of peripheral CD4+ T cells (J:45185)

• reduction in the CD4+CD8- cell population in the thymus and periphery (J:4119)

increased CD8-positive, alpha-beta T cell number ( J:4119 )

• increase in CD4-CD8+ cell population in the thymus and periphery

abnormal antigen presentation ( J:4119 )

• antigen presenting cells (APCs) had defective proteine and peptide presentation

abnormal level of surface class II molecules ( J:45185 )

• abnormal level of surface class II molecules on B cells

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:45185 , J:4119 )

• reduced number of peripheral CD4+ T cells (J:45185)

• reduction in the CD4+CD8- cell population in the thymus and periphery (J:4119)

increased CD8-positive, alpha-beta T cell number ( J:4119 )

• increase in CD4-CD8+ cell population in the thymus and periphery