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Phenotypes Associated with This Genotype
Genotype
MGI:2385830
Allelic
Composition
Slc26a4tm1Egr/Slc26a4tm1Egr
Genetic
Background
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc26a4tm1Egr mutation (1 available); any Slc26a4 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• failed to exhibit a Preyer's reflex to a loud clap
• impairment on a rotarod test
• pronounced head bobbing at 3 weeks of age
• pronounced head tilting at 3 weeks of age
• gait unsteadiness evident upon beginning to walk
• profound circling behavior at 3 weeks of age

hearing/vestibular/ear
• defects detectable at E15
• bulging due to dilation of scala media observed at P1
• dilated cochlea observed at E15.5-E16.5
• in some cases, IHC degeneration is associated with enlarged stereocilia
• inner hair cell degeneration starting between P7 and P15, with variation among different cochleas as well as areas of the same cochlea
• outer hair cell degeneration starting between P7 and P15, with considerable variation among different cochleas as well as areas of the same cochlea
• dilated scala media at P1
• some mice develop dilated semicircular canals
• dilated saccule observed at E15.5-E16.5
• dilated endolymphatic duct starting at E15
• dilated endolymphatic sac starting at E15
• destruction of the otoconial membrane
• almost complete absence of otoconia
• at P30, occasional presence of giant otoconia, when present
• failed to show characteristic waveforms by auditory-evoked brainstem response analyses
• at P28-P42, homozygotes show no characteristic ABR waveforms at intensities up to 100 dB SPL and with all four test stimuli, indicating complete hearing loss
• ~50% of homozygotes exhibit various signs of vestibular dysfunction, including habitual circling behaviour, head-tilting and head-bobbing and/or an abnormal reaching response
• vestibular dysfunction shows variable expressivity with respect to its presence, features and severity, but not age of onset

nervous system
• in some cases, IHC degeneration is associated with enlarged stereocilia
• inner hair cell degeneration starting between P7 and P15, with variation among different cochleas as well as areas of the same cochlea
• outer hair cell degeneration starting between P7 and P15, with considerable variation among different cochleas as well as areas of the same cochlea

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Pendred Syndrome DOID:0060744 OMIM:274600
J:67072


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory