Phenotypes Associated with This Genotype

Genotype
MGI:2385755

• Allelic Composition: Tg(App)1874Kha/?
• Genetic Background: FVB/N-Tg(App)1874Kha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:29880 )

• 50% of mutant mice are dead at 119 days of age

behavior/neurological

abnormal anxiety-related response ( J:29880 )

• 54% of mutant mice are neophobic at 100 days of age

nervous system

abnormal astrocyte morphology ( J:29880 )

• hypertrophic astrocytes observed in the parahippocampal area, hippocampus, amygdala, and cerebral cortex