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Phenotypes Associated with This Genotype
Genotype
MGI:2385751
Allelic
Composition
Tg(UcpDta)1Kz/?
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(UcpDta)1Kz mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• by 19 weeks, mice had greater than 50% body fat (J:78211)
• by 19 weeks, mice had greater than 50% body fat (J:78211)
• by 27 weeks, mice were nearly double the weight of controls (J:78211)
• by 27 weeks, mice were nearly double the weight of controls (J:78211)
• evident at 16 days of age and progressive (J:78211)
• evident at 16 days of age and progressive (J:78211)

adipose tissue
• lacked brown adipose tissue (J:78211)
• lacked brown adipose tissue (J:78211)
• by 19 weeks, mice had greater than 50% body fat (J:78211)
• by 19 weeks, mice had greater than 50% body fat (J:78211)

homeostasis/metabolism
N
• normal corticosterone levels (J:78211)
• normal corticosterone levels (J:78211)
• hyperinsulinemia (J:78211)
• hyperinsulinemia (J:78211)
• hypercholesterolemia (J:78211)
• hypercholesterolemia (J:78211)
• hypertriglyceridemia (J:78211)
• hypertriglyceridemia (J:78211)
• plasma triglyceride is dramatically increased over that of non-transgenic controls, and this can be reduced by hepatic overexpression of lipin 1 (J:147417)
• plasma triglyceride is dramatically increased over that of non-transgenic controls, and this can be reduced by hepatic overexpression of lipin 1 (J:147417)

behavior/neurological
• beginning at 5-7 weeks (J:78211)
• beginning at 5-7 weeks (J:78211)

nervous system
N
• histologically normal hypothalamus (J:78211)
• histologically normal hypothalamus (J:78211)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:78211


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory