Mouse Genome Informatics
tg
    Tg(UcpDta)1Kz/?
involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• by 19 weeks, mice had greater than 50% body fat
• by 27 weeks, mice were nearly double the weight of controls
• evident at 16 days of age and progressive

adipose tissue
• lacked brown adipose tissue
• by 19 weeks, mice had greater than 50% body fat

homeostasis/metabolism
N
• normal corticosterone levels (J:78211)
• hypertriglyceridemia
• plasma triglyceride is dramatically increased over that of non-transgenic controls, and this can be reduced by hepatic overexpression of lipin 1

behavior/neurological
• beginning at 5-7 weeks

nervous system
N
• histologically normal hypothalamus (J:78211)

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:78211