Phenotypes Associated with This Genotype

Genotype
MGI:2183475

• Allelic Composition: Nodal^tm2Rob/Nodal^tm2Rob
• Genetic Background: involves: 129S/SvEv * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:77125 )

• all mice die by 6 weeks of age

prenatal lethality, incomplete penetrance ( J:77125 )

• 30% of mice survive to birth

cardiovascular system

aortic hypertrophy ( J:77125 )

abnormal heart looping ( J:77125 )

• at E9.5, the heart loops ventrally instead of laterally as in wild-type mice

abnormal heart apex morphology ( J:77125 )

• at E11.5, heart apex is ambiguously positioned unlike in wild-type mice

abnormal heart position or orientation ( J:77125 )

• at E9.0, the heart is positioned more ventrally than normal

respiratory system

right pulmonary isomerism ( J:77125 )

• mutant embryos have 4 right lobes and 2 or 3 left lobes, indicating partial right pulmonary isomerism

embryo

embryo phenotype ( J:77125 )

N • mice exhibit normal gastrulation

growth/size/body

decreased body size ( J:77125 )

• mice are runted

right-sided isomerism ( J:77125 )

• partial

right pulmonary isomerism ( J:77125 )

• mutant embryos have 4 right lobes and 2 or 3 left lobes, indicating partial right pulmonary isomerism