Phenotypes Associated with This Genotype

Genotype
MGI:2183396

• Allelic Composition: Msh5^tm1Rak/Msh5^tm1Rak
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

ovary cyst ( J:51921 )

♀ • by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts

ovary degeneration ( J:51921 )

♀ • normal in size at birth, but degenerate progressively to become rudimentary by adulthood

small testis ( J:51921 )

♂ • 70% reduction in size

reproductive system

decreased oocyte number ( J:51921 )

♀ • oocyte numbers declined steadily with degeneration of ovaries

azoospermia ( J:51921 )

♂

abnormal female meiosis ( J:51921 )

♀

abnormal male meiosis ( J:51921 , J:62204 )

♂ • abnormal chromosomal pairing (J:51921)

♂ (J:62204)

ovary cyst ( J:51921 )

♀ • by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts

ovary degeneration ( J:51921 )

♀ • normal in size at birth, but degenerate progressively to become rudimentary by adulthood

small testis ( J:51921 )

♂ • 70% reduction in size

female infertility ( J:51921 )

♀

male infertility ( J:51921 )

♂

growth/size/body

ovary cyst ( J:51921 )

♀ • by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts

abnormal ovarian bursa morphology ( J:51921 )

♀ • by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts

cellular

decreased oocyte number ( J:51921 )

♀ • oocyte numbers declined steadily with degeneration of ovaries

azoospermia ( J:51921 )

♂

abnormal female meiosis ( J:51921 )

♀

abnormal male meiosis ( J:51921 , J:62204 )

♂ • abnormal chromosomal pairing (J:51921)

♂ (J:62204)