Phenotypes Associated with This Genotype

Genotype
MGI:2183209

• Allelic Composition: Ascl1^tm1And/Ascl1^tm1And
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15850 )

• animals die within 24 hours of birth

pigmentation

abnormal skin pigmentation ( J:15850 )

• gray appearance in 25% of animals

behavior/neurological

absent gastric milk in neonates ( J:15850 )

• neonates did not feed; no milk in stomach after 6-12 hours

respiratory system

abnormal olfactory epithelium morphology ( J:15850 )

• thinner than normal

abnormal olfactory sensory neuron morphology ( J:15850 )

• absent olfactory neurons; very few remaining cells in epithelium; precursors do not form

• normal sustentacular cells

respiratory distress ( J:15850 )

• difficulty in breathing, deep gasping movements apparent

taste/olfaction

abnormal olfactory epithelium morphology ( J:15850 )

• thinner than normal

abnormal olfactory sensory neuron morphology ( J:15850 )

• absent olfactory neurons; very few remaining cells in epithelium; precursors do not form

• normal sustentacular cells

nervous system

abnormal olfactory sensory neuron morphology ( J:15850 )

• absent olfactory neurons; very few remaining cells in epithelium; precursors do not form

• normal sustentacular cells

abnormal enteric neuron morphology ( J:15850 )

• delayed myenteric neuron development

absent enteric neurons ( J:15850 )

abnormal parasympathetic ganglion morphology ( J:15850 )

abnormal sympathetic ganglion morphology ( J:15850 )

craniofacial

abnormal olfactory epithelium morphology ( J:15850 )

• thinner than normal

abnormal olfactory sensory neuron morphology ( J:15850 )

• absent olfactory neurons; very few remaining cells in epithelium; precursors do not form

• normal sustentacular cells

integument

abnormal skin pigmentation ( J:15850 )

• gray appearance in 25% of animals

growth/size/body

abnormal olfactory epithelium morphology ( J:15850 )

• thinner than normal

abnormal olfactory sensory neuron morphology ( J:15850 )

• absent olfactory neurons; very few remaining cells in epithelium; precursors do not form

• normal sustentacular cells