Mouse Genome Informatics
hm
    Pkd1m1Bei/Pkd1m1Bei
involves: A/J * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands

homeostasis/metabolism
• described as severe

renal/urinary system
• described as massively cystic by histological analysis (J:75360)
• cultured kidneys show 3-fold higher cystogenic potentials than controls and treatment of these cultures with Gant61, a small molecule GLI antagonist, or Sant2, a small molecule SMO antagonist, inhibitors reduces cystogenic potential (J:213263)

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:75360