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Phenotypes Associated with This Genotype
Genotype
MGI:2181896
Allelic
Composition
Pkd1m1Bei/Pkd1m1Bei
Genetic
Background
involves: A/J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1m1Bei mutation (1 available); any Pkd1 mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands

homeostasis/metabolism
• described as severe

renal/urinary system
• described as massively cystic by histological analysis (J:75360)
• cultured kidneys show 3-fold higher cystogenic potentials than controls and treatment of these cultures with Gant61, a small molecule GLI antagonist, or Sant2, a small molecule SMO antagonist, inhibitors reduces cystogenic potential (J:213263)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive polycystic kidney disease DOID:0110861 OMIM:263200
J:75360


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory