Phenotypes for Lats1 MGI:2181697 MGI Mouse

neonatal lethality, incomplete penetrance ( J:52536 )

• incomplete penetrance, many mutant pups (60/101) dead during first postnatal day

postnatal lethality, incomplete penetrance ( J:52536 )

• of mice that survive the neonatal period, only 8% survive to three weeks of age

decreased body weight ( J:52536 )

• weight at birth was approximately 70% of normal

• of mice that survived, weight remained at 60 - 70% of controls

increased ovary tumor incidence ( J:52536 )

• females developed ovarian stromal cell tumors by 3 months of age

abnormal female reproductive system morphology ( J:52536 )

absent corpus luteum ( J:52536 )

• corpus luteum formation lacking

abnormal ovarian follicle morphology ( J:52536 )

• less prominent formation of the follicular antrum

• fewer degenerative granulosa cells in the follicles

decreased mature ovarian follicle number ( J:52536 )

• any follicles seen were primary or secondary

impaired ovarian folliculogenesis ( J:52536 )

• ovaries contained fewer follicles than age- and parity-matched controls

absent estrous cycle ( J:52536 )

• females remained in continual metestrous, never cycling

abnormal fertility/fecundity ( J:52536 )

female infertility ( J:52536 )

• incomplete penetrance; 60% of females are completely sterile

reduced fertility ( J:52536 )

• decreased fertility, both males and females

decreased circulating luteinizing hormone level ( J:52536 )

• females had reduced serum concentrations

decreased circulating prolactin level ( J:52536 )

• females had reduced serum concentrations

decreased circulating growth hormone level ( J:52536 )

• females had reduced serum concentrations

internal hemorrhage ( J:52536 )

• neonatal death was accompanied by evidence of internal hemorrhage into vital organs

increased ovary tumor incidence ( J:52536 )

• females developed ovarian stromal cell tumors by 3 months of age

increased sarcoma incidence ( J:52536 )

• 14.3% of females, aged 4 to 10 months, developed large soft-tissue sarcomas

adenohypophysis hyperplasia ( J:52536 )

• hyperplastic pituitaries, restricted to the anterior lobe

abnormal mammary gland development ( J:52536 )

• decreased amount of breast epithelial tissue, with complete absence of nipple formation in some females

• mammary glands reduced to a fat pad devoid of ductular component

absent nipple ( J:52536 )

• complete absence of nipple formation in some females

absent corpus luteum ( J:52536 )

• corpus luteum formation lacking

abnormal ovarian follicle morphology ( J:52536 )

• less prominent formation of the follicular antrum

• fewer degenerative granulosa cells in the follicles

decreased mature ovarian follicle number ( J:52536 )

• any follicles seen were primary or secondary

impaired ovarian folliculogenesis ( J:52536 )

• ovaries contained fewer follicles than age- and parity-matched controls

increased ovary tumor incidence ( J:52536 )

• females developed ovarian stromal cell tumors by 3 months of age

adenohypophysis hyperplasia ( J:52536 )

• hyperplastic pituitaries, restricted to the anterior lobe

abnormal mammary gland development ( J:52536 )

• decreased amount of breast epithelial tissue, with complete absence of nipple formation in some females

• mammary glands reduced to a fat pad devoid of ductular component

absent nipple ( J:52536 )

• complete absence of nipple formation in some females

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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