Phenotypes Associated with This Genotype

Genotype
MGI:2181574

• Allelic Composition: Fgfr1^tm6.1Jrt/Fgfr1^tm6.1Jrt
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal axial skeleton morphology ( J:49154 )

abnormal sternocostal joint morphology ( J:49154 )

• R7 (45%) is not attached to the sternum of newborn mice

rib fusion ( J:49154 )

• rib fusion (21%) occurs in newborn mice

abnormal vertebrae morphology ( J:49154 )

• vertebral transformations to posterior direction

• however, the number of caudal vertebrae is not reduced

thoracic vertebral transformation ( J:49154 )

• transformations of T1 to T2 (9.1%), T12 to L1 (4.5%), and T13 to L1 (55%)

cervical vertebral transformation ( J:49154 )

• transformations of C5 to C6 (9.1%), C6 to C7 (13.6%), and C7 to T1 (59%)

lumbar vertebral transformation ( J:49154 )

• transformation of L5 to S1 (4.5%) and L6 to S1 (73%)

sacral vertebral transformation ( J:49154 )

• transformation of S1 to S2 (59%) and S3 to S4 (23%)