Phenotypes Associated with This Genotype

Genotype
MGI:2181567

• Allelic Composition: Fgfr1^tm3.1Jrt/Fgfr1^tm3.1Jrt
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:49154 )

• a number of homozygous mutant embryos are found dead or resorbed at E9.5

embryo

abnormal gastrulation ( J:49154 )

• at E9.5, homozygotes display a gastrulation defect

decreased paraxial mesoderm size ( J:49154 )

• at E9.5, the amount of Mox-1-positive paraxial mesoderm is reduced

abnormal somite development ( J:49154 )

• at E9.5, paraxial mesoderm is not organized into somites

absent somites ( J:49154 )

• at E9.5, homozygotes show absence of somite formation