Phenotypes Associated with This Genotype

Genotype
MGI:2181403

• Allelic Composition: Creb1^tm1Gsc/Creb1^tm1Gsc
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:18749 )

• fewer than expected mice survive to adulthood (15% compared to an expected 25%)

• however, surviving mice exhibit normal histology and morphology

postnatal lethality ( J:18749 )

• fewer than expected mice survive to adulthood (15% compared to an expected 25%)

• however, surviving mice exhibit normal histology and morphology

behavior/neurological

abnormal behavioral response to addictive substance ( J:34605 )

• at high doses, mice develop a tolerance to morphine analgesia compared to wild-type mice

decreased behavioral withdrawal response ( J:34605 )

• following treatment with naloxone, mice chronically treated with morphine exhibit reduced withdrawal symptoms with no signs of sniffing or pstosis compared to similarly treated wild-type mice

abnormal cued conditioning behavior ( J:20672 )

• 2 and 24 hours after cued conditioning, all but 2 mice exhibit reduced freezing compared to wild-type mice

• mice receiving extra training still perform worse than wild-type mice

• however, cued conditioning after 30 and 60 minutes is normal

abnormal spatial learning ( J:20672 )

• while intensive training improves performance, mice perform worse than wild-type mice in a Morris water maze

abnormal temporal memory ( J:20672 )

• regardless of additional training, mice exhibit defects in long-term memory following contextual and cued conditioning compared to wild-type mice

abnormal contextual conditioning behavior ( J:20672 )

• 60 minutes and 24 hours after contextual conditioning, all but 1 mouse exhibit reduced freezing compared to wild-type mice

• mice receiving extra training still perform worse than wild-type mice

• however, contextual conditioning 30 minutes after conditioning is normal

decreased vertical activity ( J:34605 )

nervous system

abnormal stellate ganglion morphology ( J:121244 )

• stellate ganglion is larger than in controls at E17.5

small superior cervical ganglion ( J:121244 )

• SCG is smaller than in controls at E17.5

abnormal CNS synaptic transmission ( J:20672 )

• the ratio of field excitatory postsynaptic potential slope to fiber volley in untetanized hippocampal slices is increased 1.6-fold compared to in wild-type slices

• however, paired pulse facilitation is normal

reduced long-term potentiation ( J:20672 )

• long term potentiation decays to baseline 90 minutes after tetanus unlike in wild-type mice that maintain stable LTP for 2 hours

• despite normal peak posttetanic potentiation, synaptic potentiation is lower than in wild-type mice as early as 10 minutes after titanic conditioning