Phenotypes Associated with This Genotype

Genotype
MGI:2181275

• Allelic Composition: Jun^tm2.1Wag/Jun^tm2.1Wag
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:53481 )

decreased body weight ( J:53481 )

• small decrease in body weight starting from the first week after birth that persists into adulthood

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:53481 )

• resistant to kainate-induced epileptic seizures, showing milder symptoms and quick recovery

cellular

decreased cellular sensitivity to ultraviolet irradiation induced cell death ( J:53481 )

• cell death in response to ultraviolet irradiation, but not the alkylating agent MNNG, is reduced in fibroblasts

decreased susceptibility to neuronal excitotoxicity ( J:53481 )

• primary cortical/hippocampal neurons are protected from apoptosis induced by the excitatory amino acid, kainate

decreased cell proliferation ( J:53481 )

• primary fibroblasts exhibit a slower proliferation rate but do not enter premature senescence or show increased cell death

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:53481 )

• resistant to kainate-induced epileptic seizures, showing milder symptoms and quick recovery

decreased susceptibility to neuronal excitotoxicity ( J:53481 )

• primary cortical/hippocampal neurons are protected from apoptosis induced by the excitatory amino acid, kainate

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:53481 )

• primary cortical/hippocampal neurons are protected from apoptosis induced by the excitatory amino acid, kainate