Mouse Genome Informatics
ot
    Zic3tm1Bca/Y
involves: 129S7/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• Background Sensitivity: no live born hemizygotes, unlike in crosses to C57BL/6 or outbred Swiss mice (J:75951)
• despite normal numbers at E9.5, fewer than expected mice at E15.5 and weaning (J:192577)

cardiovascular system
• in some mice (J:192577)
• interruption in some mice (J:192577)
• in 4 of 18 mice at E9.5 (J:192577)
• sinisteral looping in some mice (J:192577)
• in some mice (J:192577)
• in some mice (J:192577)
• in some mice (J:192577)

craniofacial
• in some mice at E9.5 (J:192577)
• in 5 of 58 mice at E15.5 (J:192577)

digestive/alimentary system
• in 5 of 58 mice at E15.5 (J:192577)
• midline and right-sided stomach in some mice (J:192577)
• in some mice (J:192577)

embryogenesis
• the teardrop structure at the distal tip of the embryo is irregular and forms non-cohesive groups of node cells (J:194989)
• cells appear larger (J:194989)
• in 5 of 58 mice at E15.5 (J:192577)
• in 12 of 18 mice (J:192577)

growth/size
• in 12 of 18 mice (J:192577)
• laterality defects in 3 of 15 mice (J:192577)
• in some mice (J:192577)
• in some mice (J:192577)
• in some mice (J:192577)

nervous system
• in 5 of 58 mice at E15.5 (J:192577)
• in 5 of 58 mice at E15.5 (J:192577)

respiratory system
• in some mice (J:192577)

Mouse Models of Human Disease
OMIM IDRef(s)
Heterotaxy, Visceral, 1, X-Linked; HTX1 306955 J:75951