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Phenotypes Associated with This Genotype
Genotype
MGI:2180831
Allelic
Composition
Zic3tm1Bca/Y
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic3tm1Bca mutation (0 available); any Zic3 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: no live born hemizygotes, unlike in crosses to C57BL/6 or outbred Swiss mice
• despite normal numbers at E9.5, fewer than expected mice at E15.5 and weaning

cardiovascular system
• in some mice
• interruption in some mice
• in 4 of 18 mice at E9.5
• sinisteral looping in some mice
• in some mice
• in some mice

craniofacial
• in 5 of 58 mice at E15.5

digestive/alimentary system
• in 5 of 58 mice at E15.5
• midline and right-sided stomach in some mice
• in some mice

embryo
• cells appear larger
• in 12 of 18 mice
• in 5 of 58 mice at E15.5
• the teardrop structure at the distal tip of the embryo is irregular and forms non-cohesive groups of node cells

growth/size/body
• in 12 of 18 mice
• in some mice at E9.5
• in 5 of 58 mice at E15.5
• laterality defects in 3 of 15 mice
• in some mice
• in some mice
• in some mice

nervous system
• in 5 of 58 mice at E15.5
• in 5 of 58 mice at E15.5

respiratory system
• in some mice

cellular

Mouse Models of Human Disease
OMIM ID Ref(s)
Heterotaxy, Visceral, 1, X-Linked; HTX1 306955 J:75951


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory