Mouse Genome Informatics
ot
    Zic3tm1Bca/Y
involves: 129S7/SvEvBrd
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: no live born hemizygotes, unlike in crosses to C57BL/6 or outbred Swiss mice
• despite normal numbers at E9.5, fewer than expected mice at E15.5 and weaning

cardiovascular system
• in some mice
• interruption in some mice
• in 4 of 18 mice at E9.5
• sinisteral looping in some mice
• in some mice
• in some mice

craniofacial
• in 5 of 58 mice at E15.5

digestive/alimentary system
• in 5 of 58 mice at E15.5
• midline and right-sided stomach in some mice
• in some mice

embryogenesis
• the teardrop structure at the distal tip of the embryo is irregular and forms non-cohesive groups of node cells
• cells appear larger
• in 5 of 58 mice at E15.5
• in 12 of 18 mice

growth/size/body
• in 12 of 18 mice
• in some mice at E9.5
• in 5 of 58 mice at E15.5
• laterality defects in 3 of 15 mice
• in some mice
• in some mice
• in some mice

nervous system
• in 5 of 58 mice at E15.5
• in 5 of 58 mice at E15.5

respiratory system
• in some mice

cellular

Mouse Models of Human Disease
OMIM IDRef(s)
Heterotaxy, Visceral, 1, X-Linked; HTX1 306955 J:75951