Phenotypes Associated with This Genotype

Genotype
MGI:2180809

• Allelic Composition: Itga4^tm1Hyn/Itga4^tm1Hyn
• Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:23140 )

• about 50% die at around E11 with failure of allantois-chorion fusion

• about 50% die around E12.5 with cardiac defects, although a few survive up to E14.5

embryo

abnormal allantois morphology ( J:23140 )

• about half of the embryos exhibit allantois defects between E9.5 and E11.5

dilated allantois ( J:23140 )

• allantois has an abnormal balloon shape

abnormal placenta morphology ( J:23140 )

• placenta lacks the allantoic component at E9.5 and as a result, the placenta does not form a connection with the embryo

failure of chorioallantoic fusion ( J:23140 )

• failure of fusion of the allantois with the chorion

cardiovascular system

abnormal cardiovascular system morphology ( J:23140 )

• the 50% of embryos that survive past E11.5 develop cardiac abnormalities between E11.5 and E14.5 but do not have allantois defects

abnormal epicardium development ( J:23140 )

• epicardium is missing on the entire ventricular surface and on part of the atrial surface at E11.5, but not at E10.5

abnormal coronary vessel morphology ( J:23140 )

• coronary vessels at the atrioventricular sulcus region are absent

heart hemorrhage ( J:23140 )

• cardiac hemorrhage

craniofacial

abnormal craniofacial morphology ( J:23140 )

• embryos with cardiac defects exhibit abnormalities in the cranial and facial structures