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Phenotypes Associated with This Genotype
Genotype
MGI:2180790
Allelic
Composition
Tbx21tm1Glm/Tbx21+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx21tm1Glm mutation (4 available); any Tbx21 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• only 42% of CD4 T cells produce high levels of Ifng compared to wild-type
• splenic NK cells from mutants produce less Ifng in response to Il-12 or Il-18 than NK cells from wild-type

immune system
• only 42% of CD4 T cells produce high levels of Ifng compared to wild-type
• splenic NK cells from mutants produce less Ifng in response to Il-12 or Il-18 than NK cells from wild-type
• increased amount of TGFb is found in bronchial alveolar lavage (BAL) fluid compared to wild-type
• increased amounts of Il-4 and Il-13 are found in BAL fluid; Il-5 levels are high in mutants and do not increase with allergen challenge as wild-type levels do
• increased amount of TNFa is found in bronchial alveolar lavage (BAL) fluid compared to wild-type

respiratory system
• mice show an increase in thickness of subbasement collagen layer of the airways, with an increased numbers of bronchial myofibroblast
• 4-5 week old homozygous mice exhibit airway hyperresponsiveness (AHR) to methacholine challenge, in the absence of prior immunologic sensitization; mice are more responsive without allergen challenge than wild-type mice following antigen challenge

homeostasis/metabolism
• increased amount of TGFb is found in bronchial alveolar lavage (BAL) fluid compared to wild-type
• increased amounts of Il-4 and Il-13 are found in BAL fluid; Il-5 levels are high in mutants and do not increase with allergen challenge as wild-type levels do
• increased amount of TNFa is found in bronchial alveolar lavage (BAL) fluid compared to wild-type

Mouse Models of Human Disease
OMIM ID Ref(s)
Asthma, Susceptibility to 600807 J:73832


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory