Mouse Genome Informatics
ht
    Tbx21tm1Glm/Tbx21+
involves: 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• only 42% of CD4 T cells produce high levels of Ifng compared to wild-type
• splenic NK cells from mutants produce less Ifng in response to Il-12 or Il-18 than NK cells from wild-type

immune system
• only 42% of CD4 T cells produce high levels of Ifng compared to wild-type
• splenic NK cells from mutants produce less Ifng in response to Il-12 or Il-18 than NK cells from wild-type
• increased amount of TGFb is found in bronchial alveolar lavage (BAL) fluid compared to wild-type
• increased amounts of Il-4 and Il-13 are found in BAL fluid; Il-5 levels are high in mutants and do not increase with allergen challenge as wild-type levels do
• increased amount of TNFa is found in bronchial alveolar lavage (BAL) fluid compared to wild-type

respiratory system
• mice show an increase in thickness of subbasement collagen layer of the airways, with an increased numbers of bronchial myofibroblast
• 4-5 week old homozygous mice exhibit airway hyperresponsiveness (AHR) to methacholine challenge, in the absence of prior immunologic sensitization; mice are more responsive without allergen challenge than wild-type mice following antigen challenge

homeostasis/metabolism
• increased amount of TGFb is found in bronchial alveolar lavage (BAL) fluid compared to wild-type
• increased amounts of Il-4 and Il-13 are found in BAL fluid; Il-5 levels are high in mutants and do not increase with allergen challenge as wild-type levels do
• increased amount of TNFa is found in bronchial alveolar lavage (BAL) fluid compared to wild-type

Mouse Models of Human Disease
OMIM IDRef(s)
Asthma, Susceptibility to 600807 J:73832