Phenotypes Associated with This Genotype

Genotype
MGI:2180702

• Allelic Composition: Vamp2^tm1Sud/Vamp2^tm1Sud
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:72714 )

• animals die immediately after birth

growth/size/body

abnormal postnatal growth/weight/body size ( J:72714 )

• rounded, curled appearance at birth

nervous system

abnormal miniature excitatory postsynaptic currents ( J:72714 )

• reduced frequency (about 15% of controls) of spontaneous miniature excitatory currents in hippocampal neurons

• single neurons stimulated at 1 Hz exhibit only rare synaptic events with small amplitudes corresponding to minis; even at high frequencies, only erratic events occur that are not completely synchronous with the stimulation

decreased neurotransmitter release ( J:72714 )

• spontaneous synaptic vesicle fusion and fusion induced by hypertonic sucrose is decreased about 10-fold and fast calcium-triggered fusion is decreased more than 100-fold, indicating that neurotransmitter release is operational but cannot be efficiently stimulated by calcium

immune system

immune system phenotype ( J:131926 )

N • homozygotes exhibit normal degranulation of mast cells