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Phenotypes Associated with This Genotype
Genotype
MGI:2180518
Allelic
Composition		 Lef1tm1Rug/Lef1tm1Rug
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lef1tm1Rug mutation (0 available); any Lef1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
absent dentate gyrus ( J:59284 )
• dentate gyrus granule cells are absent but glial cells and interneurons are present in this region
• dentate gyrus is absent at E16.5, E18.5, and P0
abnormal hippocampus region morphology ( J:59284 )
• abnormal appearance of the CA fields of the hippocampus

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory