Phenotypes Associated with This Genotype

Genotype
MGI:2180209

• Allelic Composition: Irf1^tm1Mak/Irf1^tm1Mak
• Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J * DBA/2)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell number ( J:64286 )

• CD8+/CD4+ T cell ratio is lower than wild-type or Irf2-deficient mice during course of LCMV infection

increased double-positive T cell number ( J:64286 )

• numbers are normal or slightly increased in thymi

increased CD4-positive, alpha-beta T cell number ( J:64286 )

• CD4+CD8- T cells are often but not always increased in number in homozygotes

decreased CD8-positive, alpha-beta T cell number ( J:64286 )

• 10-fold reduction in TCR alpha-beta CD4-CD8+ T cells is observed in peripheral blood, spleen, thymus, and lymph nodes

immune system

immune system phenotype ( J:64286 )

N • humoral response to vesicular stomatitis virus challenge is normal; kinetics of immunoglobulin class switching and antibody levels are comparable to wild-type mice

abnormal T cell number ( J:64286 )

• CD8+/CD4+ T cell ratio is lower than wild-type or Irf2-deficient mice during course of LCMV infection

increased double-positive T cell number ( J:64286 )

• numbers are normal or slightly increased in thymi

increased CD4-positive, alpha-beta T cell number ( J:64286 )

• CD4+CD8- T cells are often but not always increased in number in homozygotes

decreased CD8-positive, alpha-beta T cell number ( J:64286 )

• 10-fold reduction in TCR alpha-beta CD4-CD8+ T cells is observed in peripheral blood, spleen, thymus, and lymph nodes

abnormal response to infection ( J:64286 )

• significantly reduced cytotoxic responses against LCMV-infected target cells are observed