Phenotypes Associated with This Genotype

Genotype
MGI:2180163

• Allelic Composition: Inhba^tm1Zuk/Inhba^tm1Zuk
• Genetic Background: either: (129S/SvEv-Inhba^tm1Zuk) or (involves: 129S7/SvEvBrd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:23923 )

• mice die within 24 hours of birth

craniofacial

abnormal alveolar process morphology ( J:23923 )

• mice display a secondary defect in the alveolar ridge of the mandible

absent incisors ( J:23923 )

absent lower incisors ( J:23923 )

• lower incisors are completely absent from 22 of 25 mice

absent hard palate ( J:23923 )

• Background Sensitivity: 7 of 22 mice (32%) on a mixed background that do not display a cleft palate lack a hard palate

cleft secondary palate ( J:23923 )

• Background Sensitivity: 12 of 42 (29%) of mice on a mixed background while 3 of 9 (33%) of mice on an inbred background have a cleft in the secondary palate

behavior/neurological

absent suckling reflex ( J:23923 )

skeleton

abnormal alveolar process morphology ( J:23923 )

• mice display a secondary defect in the alveolar ridge of the mandible

absent incisors ( J:23923 )

absent lower incisors ( J:23923 )

• lower incisors are completely absent from 22 of 25 mice

digestive/alimentary system

absent hard palate ( J:23923 )

• Background Sensitivity: 7 of 22 mice (32%) on a mixed background that do not display a cleft palate lack a hard palate

cleft secondary palate ( J:23923 )

• Background Sensitivity: 12 of 42 (29%) of mice on a mixed background while 3 of 9 (33%) of mice on an inbred background have a cleft in the secondary palate

integument

abnormal vibrissa follicle morphology ( J:23923 )

• growth and/or differentiation of whisker follicles is delayed

• if present, the root sheath is immature

• cells at the base of the hair bulb are irregular in pattern

• papilla lies closer to the surface

absent vibrissae ( J:23923 )

• mice are born without vibrissae

growth/size/body

abnormal alveolar process morphology ( J:23923 )

• mice display a secondary defect in the alveolar ridge of the mandible

absent incisors ( J:23923 )

absent lower incisors ( J:23923 )

• lower incisors are completely absent from 22 of 25 mice

absent hard palate ( J:23923 )

• Background Sensitivity: 7 of 22 mice (32%) on a mixed background that do not display a cleft palate lack a hard palate

cleft secondary palate ( J:23923 )

• Background Sensitivity: 12 of 42 (29%) of mice on a mixed background while 3 of 9 (33%) of mice on an inbred background have a cleft in the secondary palate